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It binds copper(II) with high affinity (association constant in the range of 10 to the power of 16 per molar, placing it among the tighter biological copper chelators)
National Vital Statistics Reports
Those same miRNAs also affect tumor suppressor genes.[ref] While a lot more research is needed here, the impact of miRNA on both tumor suppressors and MTHFR may be part of why folate is both beneficial for preventing cancer and then detrimental during some types of cancer
doi: 10.3390/biomedicines11112994 158 JiaX.ZhangS.TanS.DuB.HeM.QinH.et al
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