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[5] Sustained NO Production - L-citrulline creates a longer-lasting elevation of plasma arginine levels compared to direct L-arginine supplementation, providing extended NO production benefits

A large retrospective cohort study published in early 2026 (Barnett et al., Cureus) matched nearly 390,000 diabetic patients on GLP-1 therapy against a similar number not on GLP-1 therapy 4

Its being developed by Eli Lilly and is currently in Phase 3 clinical trials for obesity and type 2 diabetes

They discovered that in my basic CBC bloodwork

Most throat symptoms will resolve with conservative management and time