Susan Wolver, M.D., medical director of the VCU Health Medical Weight Loss Program, has been prescribing GLP-1 receptor agonists since they were first approved by the U.S
Clinical Evidence Pivotal Studies and Randomized Controlled Trial Evidence Description of Studies Study 023 was a phase III, open-label trial with a 14-week, randomized, double-blind, placebo-controlled period followed by a 52-week, open-label period that aimed to evaluate the efficacy and safety of setmelanotide (1 mg to 3 mg daily by subcutaneous [SC] injection) in patients aged greater than or equal to 6 years with BBS or Alstrm syndrome (AS) and obesity
In March 2025, Mounjaro prescriptions were also approved
What Should I Expect the First Week of Semaglutide GLP-1
Trial results vary by drug, dose, baseline weight, adherence, side-effect tolerance, and whether patients can stay on treatment
People tracking their food choices on semaglutide find that these hit the sweet spot without derailing progress