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In the natural aging + FOXO4-DRI group, mice received intraperitoneal injections of FOXO4-DRI (5 mg/kg, MCE, HY-P4157) every 2 days during the same period, followed by tissue collection

The research team reported the following changes in HbA1c at 52 weeks: Orfoglipron 12 mg group: -1.71% Orfoglipron 36 mg group: -1.91% Oral semaglutide 7mg group: -1.23% Oral semaglutide 14mg group: -1.47% The research team confirmed that the study achieved its primary endpoint of non-inferiority, which indicates that the new drug (orfogliprone) is not inferior to the existing drug (oral semaglutide) in clinical trials

Sodium-glucose cotransporter-2 inhibitors and risk of diabetic ketoacidosis among adults with type 2 diabetes: A systematic review and meta-analysis

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While using this medication, tell your provider right away if you notice any signs or symptoms of thyroid tumors, including unusual growth or lump in the neck, difficulty swallowing, shortness of breath, or unusual/lasting hoarseness