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These enlarged areas reduce medication absorption and can create uncomfortable injection experiences during future doses

Weight reduction: Clinical trials report substantial bodyweight loss (up to ~11 kg more than GLP1 RA comparators over 26 weeks at higher doses) [3] [4]

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Proponents suggest that sermorelin's potential to increase lean muscle mass and improve body composition might complement tirzepatide's proven weight loss effects, theoretically resulting in fat loss whilst preserving or enhancing muscle tissue