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Increased leptin also causes an increase in metabolic rate

note the peptide's favorable tolerability profile across multiple rodent studies, with no reported organ toxicity at research doses [1,2]

doi: 10.1038/s41598-017-11004-7 23 PedreBTalwarDBarayeuUSchillingDLuzarowskiMSokolowskiMet al

Specifically, a recent systematic review of 16 basic science studies showed cortisone may decrease tenocyte (tendon cell) viability and function while also weakening the structure of the tendon (Puzzitiello et al., Arthrosc Sport Med Rehabil , 2020)

Over time, chronic energy deficiency can lead to fatigue, poor recovery, loss of muscle, hormonal disturbances, low energy availability and impaired performance a condition akin to RED-S (Relative Energy Deficiency in Sport)

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