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Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch signaling In a series of studies in our and collaborating laboratories (although predominantly using colorectal cancer-originated tissue and cell lines), we have observed an intriguing inverse correlation between claudin-7 and claudin-1 expressions

For people who cannot tolerate GI side effects or who have medical conditions that make GLP-1 agonists risky, this safety differential is not a minor footnote

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