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Limited brain penetration of agonists: Studies using fluorescently labelled GLP-1 receptor agonists like semaglutide and liraglutide have shown very limited penetration into most brain regions beyond the circumventricular organs areas where the bloodbrain barrier is less effective and allows the brain to sample blood contents

Food preferences may shift, with some individuals experiencing reduced cravings for high-fat or high-sugar foods

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The presence of premonitory mood disturbance was dissociated from clinically significant anxiety and depression, as determined by HADS-A and HADS-D scores, suggesting the biological mechanisms underpinning premonitory mood symptoms may be distinct from those of mood disorders

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