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A 6 to 12-week usage period followed by a 4 to 8-week break reflects the referenced clinical guidance available, according to a review published in Rupa Health

Exposures Two cohorts were assembled, with the first composed of patients who started and continued on GLP-1 receptor agonists or DPP-4 inhibitors between 1 January 2007 and 31 December 2020 and the second composed of patients who started and continued on GLP-1 receptor agonists or SGLT-2 inhibitors between 1 January 1 2013 and 31 December 2020

Bergenstal RM, Kendall DM, Franz MJ, et al

This probiotic intervention enhanced the richness and diversity of key microbiota taxa, particularly Helicobacter and Barnesiella , with a profound reduction in serum uremic toxins IS, IAA, and TMAO levels

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