glp-1 rebound weight gain after stopping semaglutide or tirzepatide is real, but it's not because the body is “damaged”—it reflects how the body adapts after weight loss. When the medication is stopped, hunger Key Facts GPs Should Know

Metformin: This medication helps your body become more sensitive to insulin and can also help reduce hunger

Many patients beginning GLP-1 therapy simultaneously reduce their food intake significantly, which can lead to muscle soreness if they do not consume adequate protein or electrolytes during this transition

Catania A, Barrajon-Catalan E, Nicolosi S, Cicirata F, Micol V

[Epub ahead of print] Astiz M et al

Unknown human safety and purity risk: there is no human safety dataset, and grey-market vials carry the usual research-chemical hazards of mislabeling, wrong potency and contamination magnified because the compound is a potent opioid

Ozempic and Wegovy contain GLP-1 only