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Stop taking SYNJARDY or SYNJARDY XR and call your healthcare provider right away or go to the nearest hospital emergency room if you get any of the following symptoms of lactic acidosis: feel very weak and tired have unusual sleepiness or sleep longer than usual have unusual (not normal) muscle pain feel cold, especially in your arms and legs have trouble breathing feel dizzy or lightheaded have unexplained stomach or intestinal problems with nausea and vomiting, or diarrhea have a slow or irregular heartbeat You have a higher chance of getting lactic acidosis with SYNJARDY or SYNJARDY XR if you: have moderate to severe kidney problems

Time at Risk The time-at-risk period began with medication initiation until the end of continuous drug exposure, defined as a gap in exposure of more than 30 days or the end of the continuous observation period

Glucagon-like peptide 1 (GLP-1) receptor agonists belong to a class of type-2 diabetes medications that mimic the function of the GLP-1 hormone secreted by the pancreas

Her vomiting was so extreme that Bjorklund lost teeth and sometimes threw up food hours after eating

Some describe this as subtle but unmistakable improvement