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This step shapes everything that follows it is not a formality

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Opioids such as oxycodone, dosed at 2.5 mg as needed, and hydromorphone at 1 mg every 6 h as needed should only be used for acute pain that is severe or unresponsive to initial therapies not for more than 3 days

If you prefer not to take a PPI, you can try H2 blockers like famotidine (Pepcid) or over-the-counter antacids for immediate relief

As depth of tumour is partly related to its age early identification of suspect lesions is paramount [18]