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However, after 3 days, there was a transient impairment of mitochondrial function, including decreased respiration, ATP production, and oxygen consumption

Since it has been shown that deficiency affects the expression of different genes in the liver, including NO-like actions that raise cGMP through elevated guanylate cyclase, biotin exerts a secondary role in controlling gene expression (147)

As with pregnancy, this is a decision to make together with a clinician who can weigh your personal situation, your feeding plans, and your health goals