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Inhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barretts-like metaplasia via KLF4

The pentose phosphate pathway can also function as an anabolic pathway that utilizes the six carbons of glucose to generate five carbon sugars, particularly ribose-5-phosphate (R5P) that is required for purine and pyrimidine nucleotide biosynthesis

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Rathor E, Arasada C, Kulkarni A, Shaikh MA

There is some evidence that it could be useful for early diagnosis as well