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10.1021/acssynbio.9b00045 ACS Synthes

This study evaluated the therapeutic potential of non-gene-edited human chemically induced pluripotent stem cell-derived neural stem cells (hCiPSC-NSCs) in a prenatal valproic acid (VPA)-induced rat model of ASD, using a dual-pathway administration strategy (intravenous systemic delivery combined with an intracerebroventricular boost)

[00:44:27] Josh: Very high

220 While IRE1 and ATF6 upregulate HRD1, prolonged ER stress downregulates bifunctional apoptosis regulator (BAR), which is known to mediate proteasomal degradation of the ER-resident IRE1 inhibitor protein Bax inhibitor-1 (BI-1), which controls IRE1 signaling

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