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It suppresses ECM degradation, counteracts RSL3 mediated inhibition of GPX4, increases intracellular GSH levels and the GSH/GSSG ratio, reduces MDA content, and inhibits activation of the MAPK/NF-KB pathways, thereby protecting chondrocytes from ferroptosis (156)

For orforglipron and oral semaglutide, the most common adverse events were nausea, diarrhea, vomiting, dyspepsia and decreased appetite

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Swerdlow et al., 2016), as well as cognitive impairment (Shirai et al., 2015) in rodent models, recapitulating key characteristics of schizophrenia

In addition to their well-known immune features, murine and human M1 and M2 macrophages differ in iron status and expression of genes in the iron regulatory network [60, 61]

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