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For comparison of continuous variables in different time points, Friedman (comparison of three time points) and Wilcoxon signed-rank test for related samples with post hoc Bonferroni corrections for multiple comparisons (comparison of two time points) were used

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However, gastrointestinal side effects such as nausea, vomiting, and diarrhoea can lead to dehydration, which may precipitate acute kidney injury if fluid intake is inadequate