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In the U.S., its often sold as a research chemical

This difference may relate to the dual GIP/GLP-1 mechanism of tirzepatide versus the GLP-1-only action of semaglutide, though this is speculative

Similarly, IL-36, a cytokine that can induce fibrosis, is found at higher levels in fibrotic intestinal tissues of CD patients (160)

PMID: 30858740

Understanding both PK and PD, helps estimate the exposure levels likely to be efficacious and the exposure levels that might induce side effects in humans

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