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Considering the promising results of the SURPASS and SURMOUNT trials, what additional factors or challenges must researchers address before adopting tirzepatide for conditions beyond Type 2 diabetes, such as non-alcoholic fatty liver disease (NAFLD)

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Overexpression of pS6, mTOR activation, calcitonin, and C-cell hyperplasia reported in in vivo suggest the increased proliferation and tumorigenesis [75, 87]

Fiorini F, Bonneau F, Le Hir H