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Inhibition of glutathione markedly enhanced H 2 O 2 - or ARS-induced cytotoxicity in HeLa and A549 cell lines but modestly enhanced the cytotoxicity of H 2 O 2 and even did not affect the cytotoxicity of ARS in HepG2 cells

With the GSH-ee experiments, mice were injected intraperitoneally with either vehicle (saline) or Glutathione ethyl ester (Cayman Chemical, 14953) for 4 days ((17-20) days post AAV-TBG-Cre treatment)

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The Phase 2 data published in the New England Journal of Medicine by Ania Jastreboff and colleagues showed 24.2% mean body weight reduction at 48 weeks on the 12 mg dose