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Despite the promise of these new therapies to address all parts of the CVD/diabetes/obesity triad, approval and broad reimbursement for all these uses are likely still a few years off

Levels of PYY are body-weight dependent, with normal weight subjects presenting with higher levels of plasma PYY than obese humans, and elevations in PYY have also been seen after weight loss, especially in combination with exercise (75)

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Additionally, the medication affects the chemoreceptor trigger zone in your brain, a region that controls the nausea responsethis dual action explains why some patients feel queasier than others depending on their genetic sensitivity to GLP-1 signaling