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These findings provide researchers with evidence that senescence contributes directly to organ dysfunction and that targeted interventions can restore functional capacity even after decline has occurred

Moreover, granulosa cells dysfunction can directly reduce oocytes quality ( Programmed cell death (PCD), a genetically controlled process of cell death (Tower, 2015), plays an important role in regulating follicular development, maintaining hormone homeostasis, and modulating ovarian reserve (Wang et al., 2023a)