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Studies in HTM cells showed that during CLAN formation, v3 integrin signaling activates the Rac1 GEF Trio ( Given the effects of v3 integrin on phagocytosis, ECM deposition and actin polymerization, it is not surprising that v3 integrin activation significantly increased IOP in C57BL/6J mice while the knockdown of v3 integrin levels in the mouse TM significantly decreased IOP ( 41 Integrin 41 is another integrin found in the TM/SC pathway (Zhou et al., 1999

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They have been in the market since the 1940s and, by 2017, their global market was valued at more than USD 130 billion [79]

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