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In a recent study, administration of exendin-4, a long-acting GLP-1RA, stimulated -cell proliferation in juvenile human islets by inducing gene expressions of calcineurin/nuclear factor of activated T cells (NFAT) signaling, a proliferating factor such as NFATC1, and a cell cycle regulator such as cyclin A1 [57]
In addition, KPV expands research applications
Diabetes Obes Metab 25(1):1835 Webster CM et al (2023) Potential contributors to variation in weight-loss response to liraglutide
Dietitians are developing protocols specifically for GLP-1 users, focusing on adequate protein intake, nutrient density, and managing side effects like nausea
Nota: 1
Nevertheless, in animal models of ischemic AKI, the involvement of PAD4 in NETs formation leads to post-ischemic kidney damage, suggesting a potential therapeutic significance of PAD4 inhibitors in post-ischemic kidney injury (103)
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