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The location of Cu B is better conserved than that of Cu A , which is in agreement with the previous observations [12,26,31] as well as with the recently elucidated crystal structure of Zn(II)-bound TRP1 [25]
The key findings from this clinical program include significant reductions in body weight and fat mass in treatment groups compared to placebo, preferential loss of abdominal and visceral adipose tissue, no changes in serum IGF-1 levels at any dose tested, no negative effects on glucose metabolism or insulin sensitivity, no significant adverse events related to metabolic or endocrine disruption, and safety profile indistinguishable from placebo for most parameters
This means you aren't getting the full molecule where you need it most
These can vary based on the specific treatment and individual response
Bibcode:2021ChPap..75.6625A