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Recent studies have shown that enhanced glycolytic turnover promotes microglial activation through H3K9 lactylation, which in turn triggers neuroinflammation and accelerates the progression of PD

however, the CIs were not expected to lie within any specific no-effect boundaries due to the large variability seen with oral semaglutide

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In the absence of evidence-based mechanistic models, the prevention and treatment of bothersome depressive symptoms associated with perimenopause is based on expert opinions and a few randomized controlled trials Depressive symptoms are clinically and probably aetiologically different from major depressive disorders