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IVW combines SNP-specific estimates calculated using Wald ratios, assuming no directional pleiotropy of each SNP ( 2.4.2 Mediation analysis A two-step MR analysis (product of coefficients method) was applied to assess mediation ( Supplementary Figure 1

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Start with the lowest effective dose, typically 30-100 micrograms daily, rather than mega-doses marketed for dramatic results

Include the fat