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GR, glucocorticoid receptor

Breaking through a plateau involves dose optimization (if not yet at maximum therapeutic dose), intensifying strength training, increasing protein intake to 25-30% of daily calories, or reducing refined carbohydrates further

Furthermore, patients report that substance cravings fully return with cessation of treatment and disappear again when treatment is resumed

Genetic variants in the GLP1R gene (such as rs6923761) are associated with differential GLP-1 receptor sensitivity and response patterns