Zare Z, Masteri Farahani R, Salehi M, Piryaei A, Ghaffari Novin M, Fadaei Fathabadi F, Mohammadi M, Dehghani-Mohammadabadi M
Eylea (aflibercept) Disease area(s): Ophthalmology Manufacturer(s): Regeneron/Bayer 2024 Sales (USD): $9.55 billion Why it sold so well: Eylea registered strong sales in 2024, driven by the introduction of Eylea HD, which received FDA approval in 2023 and is an 8 mg formulation offering extended dosing intervals for retinal diseases
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Their BP-lowering mechanisms include weight loss, vasodilation, natriuresis, although exact mechanisms remain incompletely understood
The same molecule Eli Lilly ran through trials, the one that posted up to 24% body-weight reduction in Phase 2
Peluso G, Nicolai R, Reda E, Benatti P, Barbarisi A, Calvani M