Malnutrition, frailty, and sarcopenia in patients with cirrhosis: 2021 practice guidance by the American Association for the Study of Liver Diseases
Retrieved from Xue, X., Ren, Z., Zhang, A., et al
The enzymatic activity of prolyl 4-hydroxylase subunit alpha 1 (P4HA1), a procollagen-proline, 2-oxoglutarate 4-dioxygenase, is crucial for collagen polypeptide chain folding into stable triple-helical molecules and consequently for ECM deposition [23]
[14] The condition can affect peripheral joints, the spine, and entheses (sites where tendons and ligaments attach to bone), leading to pain, stiffness, swelling, and progressive joint damage if left untreated
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At one year, the mean percentage change in body weight was -15.3% for those taking tirzepatide versus -8.3% for those taking semaglutide.