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Narayanan S, de Mores AR, Cohen L, Anwar MM, Lazar F, Hicklen R, et al

These medications are typically prescribed along with lifestyle changes such as healthy eating and physical activity

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Current clinical guidelines from major organizations including the American Diabetes Association (ADA) and the American Gastroenterological Association (AGA) do not specifically address combining tirzepatide with orlistat, reflecting the absence of robust clinical trial data for this combination