This observation, combined with evidence that older adults have blunted MOTS-c responses to exercise, supports the hypothesis that declining mitochondrial peptide signaling contributes to the reduced exercise adaptability seen in aging
So there's a homeostatic mechanism that might explain some of these anhedonia side effects that people are reporting
A similar clinical trial using an older GLP-1 medication found that, in a cohort of 200 patients, those receiving the drug showed 18% slower cognitive decline and 50% slower shrinkage of the brain over a year
It is essential for DNA synthesis, red blood cell formation, and neurological function
Neuron 109 , 461472.e465 (2021)
Bypasses gut absorption issues: Ideal when supplements upset your stomach or conditions like IBS/Crohns reduce uptake