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We found distinctive changes in the plasma metabolome of APP carriers relative to healthy individuals, characterized by a reduction in the NAD + precursor trigonelline 27 and allose, a stereoisomer of glucose (Fig

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Whats more, the deficiency of GPX4 did not enhance the ER stress signal induced by H 2 O 2 , while in the absence of SELS, the lack of GPX4 would cause further deterioration of the ER stress signal