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Thats why Semaglutide is widely considered a breakthrough: it addresses the biological drivers of weight gain, not just behavior, and turns short bursts of effort into long-term momentum

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Absolute RPEs (absRPE, a signal that has been previously associated with salience and surprise 4 ) were estimated from computational modeling of task performance and used to estimate whether the magnitude of DA release in associative striatum correlates with the magnitude of absRPE and general sensitivity to RPEs

doi: 10.1016/j.arr.2023.102066 49 ImaiHMatsuokaMKumagaiTSakamotoTKoumuraT

Regarding the background characteristics, continuous variables were analyzed with independent samples t-test or Wilcoxon rank-sum test and categorical variables with Pearson Chi-square test