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Abstract Glucagon-like peptide-1 medicines are being prescribed to growing numbers of patients worldwide, for type 2 diabetes, obesity and associated comorbidities, including cardiovascular disease, peripheral artery disease and obstructive sleep apnea, and are revolutionizing public health strategies for these conditions

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The insulin-enhancing effects of GIP and GLP-1 were discovered over 25 years ago, yet new roles for incretin hormones continue to emerge [30]

It is worth noting that the improved glucose metabolism observed after MB07811 treatment was not accompanied by any changes in body weight (BW) and food intake (Supplementary Fig