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This is why the larger phase 3 and cardiovascular outcomes trials are essential

doi:10.1155/2013/240702 Lete, I., Mendoza, N., de la Viuda, E., & Carmona, F

(ii) Except as specified in paragraph (f)(4)(iii) of this section, if no end date is indicated on the ACO's application or otherwise provided to CMS in a form and manner specified by CMS, described in paragraph (f)(4)(i) of this section, CMS applies a 90-day duration for purposes of determining the time period during which the ACO was affected by the extreme and uncontrollable circumstance

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Many studies have flaws, sample sizes can be quite small, and we still dont know the best dosages