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Bellini, E

In this study, the intestinal microenvironment was recapitulated by applying defined mechanical deformations and fluid hydrodynamics, exploiting a coculture with a host microbiome while allowing the real-time monitoring of cell morphology and cell-cell interactions, in a manner not possible with a standard organoid culture

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On top of that, multiple doses can be administered if needed

Based on this inspiration, we propose a strategy to effectively amplify PDT by depleting endogenous GSH, and generate active molecules that are more lethal to biofilms by utilizing endogenous GSH, thus facilitating the eradication of biofilms

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