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DPP-4 inhibitors effectively prolong incretin hormone activity, enhancing glucose-dependent insulin secretion, whereas GLP-1 RAs mimic GLP-1 to promote insulin secretion and slow gastric emptying

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This continuous support is particularly helpful during the early stages of treatment when side effects and adjustments are most common

GLP-1R, together with four other glucagon receptors (GCGR, GLP-2R, GIPR, and GHRHR), belongs to the secretin (class B1) GPCR family, whose endogenous ligands are peptide hormones

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The weekly injectable Trulicity from Eli Lilly is a close substitute