Some people may be born with a change in the GSS gene responsible for producing glutathione synthetase, the enzyme that produces glutathione
62 illustrated the change in microbiome composition with an increase in Actinobacteria and Deferribacteres following NR supplementation on alcohol-exposed mice
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Although biochemically separated from the GSH system, the Trx system shares NADPH as a common reducing cofactor and serves as an alternative pathway for reducing disulfide bonds, making this system especially relevant if the GSH system has been compromised or rendered dysfunctional (Silva-Adaya et al., 2014)
6 The environment also plays a role in the spread of resistance
Some scientific studies found that whey protein supplements increase levels of glutathione and, therefore, reduce oxidative stress (4)