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Efficacy and safety of lixilan, a titratable fixed-ratio combination of lixisenatide and insulin glargine, versus insulin glargine in type 2 diabetes inadequately controlled on metformin monotherapy: the LixiLan proof-of-concept randomized trial

For persistent nausea, short-term antiemetic therapy may be considered, though with important restrictions: metoclopramide should be limited to a maximum 5-day course with appropriate dose limits as per MHRA guidance, whilst domperidone should only be used when benefits clearly outweigh risks, with assessment for cardiac risk factors and QT prolongation

Activation of the canonical pathway is initiated by the binding of Wnt ligands to the Frizzled (FZD) receptor and the low-density lipoprotein receptor-related protein (LRP) 5/6 co-receptor complex, thereby triggering intracellular signal transduction [145]

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