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After nearly 20 years of data, we can confidently say that there are no significant adverse cardiovascular complications

doi: 10.1016/j.neuropharm.2017.08.022 81 HuangJLiuYChengLLiJZhangTZhaoGet al

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Whereas Viagra and Cialis are known to widen blood vessels and lower blood pressure, PT-141s mechanism of action suggests it would have no such hemodynamic effect.10 Somewhat corroborating this supposition is a 2020 study in women that showed negligible effects on blood pressure.11 Therefore (and, again, in theory ), it could serve as a substitute ED medication for men with heart conditions