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Transgenic overexpression of fumarase in these rats increases NO and the ratio of L-arginine/citrulline in the renal outer medulla and abolishes hypertension and renal injury that may be attributed to Nos3 heterozygous mutation 88

doi: 10.1146/annurev-food-032519-051834 251

These mechanisms have been demonstrated primarily in laboratory and animal studies

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TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

Enzyme expression was induced by adding 100 M isopropyl -d-1-thiogalactopyranoside, and the cultures were incubated for another 20.5 h at 20 C, 300 rpm, 5 cm shaking diameter