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Kahleova H, Tura A, Klementova M, et al

Psoriasis: Diagnosis & Treatment

Trends in cardiovascular medicine , 33(3), 159166

Although the actual mechanisms of MTX-induced liver and kidney damage are unknown, one of the hypotheses is the breakdown in cellular antioxidant defences, which increases the production of reactive oxygen species and nitrogen species, inhibits cytosolic NADP-dependent dehydrogenase and NADP malic enzyme, lowers glutathione (GSH), superoxide dismutase (SOD) and catalase levels and reduces the effectiveness of the antioxidant defence system protecting the cell against reactive oxygen species (Reference Savran, Cicek and Doguc7)

While both are designed to help manage Type 2 diabetes and support weight loss, they work in slightly different ways and have unique results

Follow Recommended Dosages: Stick to the recommended dosage guidelines provided by the manufacturer or consult with a healthcare professional for personalized advice