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Discontinuation and Duration Dependent Cardiovascular Risk Compared with continual use of GLP-1s, discontinuing treatment for 6 months was associated with a 4% increased risk of major adverse cardiovascular events

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Cons Much shorter lifespan

261 In addition, the H19 sponge cell miR-130a induces PPAR nuclear translocation, thereby activating the transcription of adipogenic genes like those encoding acetyl coenzyme a carboxylase 1 (ACC1), fatty acid synthase (FAS), and cytochrome c oxidase (SCO1), thereby promoting intracellular lipid accumulation

Eggs, salmon, tofu, legumes, and dairy all help