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Those splitting doses typically inject in the morning and evening, 12 hours apart

It increases satiety and decreases hunger, and is believed to work by influencing serotonin signaling (Gold Standard 2015b)

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It has been safely used in a number of preclinical and clinical trials

Retatrutide's dosing protocol typically involves gradual escalation starting from 2 mg weekly, increasing by 2-4 mg increments every 4 weeks until the target maintenance dose is achieved