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The matrix physically blocks drug penetration, and bacteria inside biofilms alter their metabolic state in ways that make standard antibiotics far less effective

The Acquired podcast that noted one out of six patients have side effects that are so severe that they discontinue the drug, and as many as 68% of people roll off it after a year. This is especially surprising since most of the weight lost due to GLP-1 medicines returns if the drug is discontinued

these are typically manageable and resolve within 24-48 hours

Manufacturing costs are high, supply is limited , and most insurance plans have strict coverage rules

Donahue, L