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Whiting et al

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QA accumulation is associated with brain inflammation and cell death, and patients with advanced CKD exhibit elevated plasma KYN metabolites and QA, which uniquely correlate with fatigue and reduced quality of life (Saliba et al., 2024), supporting the role of gut-derived KYN metabolites in linking CKD to neuroinflammation

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Integrated bioinformatics analysis further revealed that elevated levels of arachidonic acid metabolism could serve as a potential biomarker for favorable prognostic outcomes in breast cancer (126)