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Elevated IGF-1 levels are associated with increased cancer risk in observational studies, particularly for hormone-sensitive tumors. Pollak, Nature Reviews Cancer Avoid use if you have: Personal or family history of cancer Undiagnosed growths or polyps A genetic predisposition to hormone-related cancers Diabetics and Individuals with Insulin Resistance IGF-1 directly affects glucose uptake and insulin signaling

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However, Huberman is still on the fence about the long-term use of rapamycin, particularly due to its immune-suppressing properties at higher doses

Its generally suggested to avoid greasy or very sugary foods, as they might lead to digestive problems for some people

Common side effects: nausea, fullness, reflux, constipation/diarrhea