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The PubMed search strategy used was: ((Insulin Resistance[MeSH Terms] OR Metabolic Syndrome[MeSH Terms] OR Glucose Intolerance[MeSH Terms] OR Prediabetic State[MeSH Terms] OR Insulin Resistance[Title/Abstract] OR Metabolic Syndrome[Title/Abstract] OR Glucose Intolerance[Title/Abstract] OR prediabetes[Title/Abstract]) AND (Akkermansia[Title/Abstract] OR Akkermansia muciniphila[Title/Abstract] OR a muciniphila[Title/Abstract] OR muciniphila[Title/Abstract])) AND ((ffrft[Filter]) AND (fft[Filter]) AND (english[Filter])) In addition to PubMed, Europe PMC was utilized to increase search sensitivity by identifying relevant full-text articles, preprints, and research outputs supported by European funding agencies, ensuring broader international coverage of the available evidence

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Certain Medications : Such as acetaminophen (Tylenol) and aspirin, which may interact negatively with glutathione