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PMID: 39509128, PMCID: PMC11544492, DOI: 10.1001/jamanetworkopen.2024.43925

The hypothesis is that GLP-1 co-agonism neutralizes that hyperglycemic effect while preserving glucagon's fat-burning and energy-expenditure benefits

Without the medications appetite-suppressing effects, some weight regain is common if healthy habits arent maintained

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The study also points to a need for researchers to shift focus from weight and body mass index to other measurements such as body composition as more informative indicators of optimal obesity management

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